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The improved dosemetric can then be used in place of traditional dose metrics(such as inhaled air concentrations or absorbed dose) in anappropriate dose–response model to provide a more accurateextrapolation to the human exposure conditions of concern.Implicit in any application of PK to risk assessment is theassumption that the toxic effects in the target tissue must berelated to the concentration of the active form(s) of thechemical in that tissue.