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Multiple stimuli,including growth and transcription factors, extra-cellular matrix (ECM) proteins, hormones, andoxygen exposure coordinated through autocrineand paracrine interactions between the epithelium,?broblast derivatives, and the ECM, work togetherin concert to sculpt the alveolar architecture (Roth-Kleiner and Post 2005). This de?nition has not been the development of air trapping

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